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modified siRNA
GenePharma has all the internationally leading core technologies of siRNA chemical synthesis, especially the custom and chemically-modified siRNA oligo synthesis technology, the RNA monomer synthesis technology,
 

Chemically-modified siRNA Oligo

GenePharma has all the internationally leading core technologies of siRNA chemical synthesis, especially the custom and chemically-modified siRNA oligo synthesis technology, the RNA monomer synthesis technology, the nucleic acid fluorescent labeling technology, and many nucleotide chemical modification technologies. 
Our siRNA products are used not only in the Chinese Academy of Sciences systems, such as the Institute of Biophysics, the Institute of Neuroscience, the Institute of Biochemistry and Shanghai Institute of Materia Medica; but also in famous Chinese universities, such as Peking University, Tsinghua University, Academy of Military Medical Sciences, Fudan University. We also get great reputation from national major hospitals. Furthermore, our products are supplied to the United States, Japan, Taiwan, Singapore, Germany, Sweden, the United Kingdom, France, South Korea and other countries and regions.

The biggest challenge of RNAi technologies is the stability of chemical synthesis. The most important goal of GenePharma chemical synthesis is to gain the best one-time experimental data. Our approach is to use theRNAi-mate transfection reagent to transfect chemically-modified siRNA into mammalian cells. Excellent results can be obtained as follows:

  • Highly efficient gene knockout
  • high specificity - for purpose target
  • High stability in serum and medium
  • minimized side effects

Comparable table of chemically-modified siRNA oligo and standard siRNA oligo

Critical challenges

Standard siRNA

chemically-modified siRNA

siRNA degradation

The non-modified standard siRNA is easy to be degraded in cell culture process. Although it is effective in most in vitro experiments, its life expectancy is shorter in cell culture.

The GenePharma chemically-modified siRNA not only increases its life expectancy in serum and cell culture, but also strengthens its in vitro application capability

Long time effect

Relative short time effect, under normal circumstances for approximately one week.

The GenePharma chemically-modified siRNA has long time effect, its effective time is twice as that of the standard siRNA

In vivo activity

The standard siRNA has poor stability, usually is not applicable to vivo experiments

The GenePharma chemically-modified siRNA has strong stability in vivo


Cat. No.

Product information

Quantity

Purification

Price

Appropriate Times

A02004

Chemically-modified siRNA

5 OD

HPLC

$174

7 business days

A02009

Chemically-modified siRNA

10 OD

HPLC

$325

7 business days

A02010

Chemically-modified siRNA

25 OD

HPLC

$674

8 business days

A02011

Chemically-modified siRNA

50 OD

HPLC

$1250

10 business days

A02012

Chemically-modified siRNA

100 OD

HPLC

$2124

15 business days

A02013

Chemically-modified siRNA

250 OD

HPLC

$3999

20-30 business days

 
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