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modified siRNA
GenePharma has all the internationally leading core technologies of siRNA chemical synthesis, especially the custom and chemically-modified siRNA oligo synthesis technology, the RNA monomer synthesis technology,
 

Chemically Modified siRNA Oligos

GenePharma is an internationally leading company in RNA synthesis technology. We specialize in siRNA chemical synthesis, with a focus on custom and chemically modified siRNA oligomers, including fluorescent labeling and an array of nucleotide chemical modifications.

The most important challenge in RNA technology is the stability of the chemically synthesized siRNAs. The primary goal of GenePharma's chemical synthesis technologies is to create chemically modified RNA products that are highly stable and efficiently transfected with our special RNAi-mate transfection reagent so that you can achieve the best result for your particular experiment, especially in mammalian and human cell lines. Our chemically modified RNA oligomers are characterized by:

  • Highly efficient transfection
  • Highly efficient target gene knockdown
  • High specificity for the target gene(s)
  • High stability in serum and medium
  • Minimized off-target gene knockdown or other side effects

 

Table 1. Comparison of standard siRNA and chemically modified siRNA oligos.

 

Standard unmodified siRNA

Chemically modified siRNA

siRNA degradation

Easily degraded in transfected cells.

Very stable and highly nuclease degradation-resistant in serum and transfected cells, without losing gene silencing capacity.

Duration of gene silencing

Relatively short time silencing effect, under normal circumstances approximately one week.

Long time silencing effect, roughly twice that of standard siRNA.

In vivo suitability

Due to its poor stability, usually not suitable for in vivo experiments. However, it is effective in most in vitro experiments.

Due to its stability and longevity, the best choice for both in vitro and in vivo studies.

 

Cat. No.

Product information

Quantity

Purification

Price

Appropriate Times

A02004

Chemically-modified siRNA

5 OD

HPLC

$174

7 business days

A02009

Chemically-modified siRNA

10 OD

HPLC

$325

7 business days

A02010

Chemically-modified siRNA

25 OD

HPLC

$674

8 business days

A02011

Chemically-modified siRNA

50 OD

HPLC

$1250

10 business days

A02012

Chemically-modified siRNA

100 OD

HPLC

$2124

15 business days

A02013

Chemically-modified siRNA

250 OD

HPLC

$3999

20-30 business days

 

 

For technical questions, email support@genepharma.com. For questions related to order placement, email bd@genepharma.com.

 
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