GenePharma’s miRNA inhibitors are chemically-modified and optimized nucleic acids designed to specifically target the microRNA (miRNA) molecules in cells. Endogenous microRNAs are small, regulatory RNAs that are expressed in animals and plants that affect the translation of target mRNAs. The mature 17-24 nucleotide, single-stranded miRNAs specifically target a protein complex to regulate translation at the level of mRNA. The miRNA inhibitors are sequence-specific and chemically-modified to specifically target and knockdown individual miRNA molecules. With Anti-miR miRNA inhibitors you can:

• Control specific miRNA activity
• Tightly regulate miRNA cellular levels
• Achieve optimal delivery efficiency with minimal cytotoxicity

Use of the miRNA inhibitors will enable miRNA functional analysis for down-regulation of miRNA activity. Specific experimental designs include:

• miRNA target site identification and validation
• Screening for miRNAs that regulate the expression of a gene
• Screening for miRNAs that affect a cellular process

Cellular functions identified by miRNA inhibitors can be further investigated with GenePharma’s miRNA Molecules, which enable loss-of-function experiments through reduction of miRNA activity.

For technical assistance, email support@genepharma.com. For questions related to order placement, email bd@genepharma.com.